There are other conditions that require short-term or longer-term anticoagulant use such as deep venous thrombosis (DVT, clot in the legs), pulmonary embolism (PE, clot in lung vessels) or after an acute myocardial infarction (MI, heart attack). When a patient with such a valid indication for anticoagulation also has a relatively high brain bleeding risk, the decision making is tricky. As extensively discussed in previous sections of this website, understanding the bleeding risk vs clot formation risk, the severity of their consequences and availability of alternative treatments should be discussed for individual patients. Involvement of expert physicians and an open discussion with patient and family are key to optimal management of these patients.